Pain Journal Club

Stay current with advances in the field of pain research!              The Pain Journal Club meets weekly during the fall and spring semesters to discuss cutting edge papers about pain, from mechanisms to circuitry. Presentations are made by Pain Center trainees (graduate student and postdocs) but the emphasis is on interactive discussions. All are welcome to attend. Students are welcome to take this as a one-credit class (MSNBIO 2651). Meetings are Tuesdays at noon in BST 1495. For more information, contact Rick Koerber (rkoerber@pitt.edu).


 

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Journal Club Schedule Fall 2017

Aug. 29th 2017 - Sarah Ross

Specialized mechanosensory nociceptors mediating rapid response to hair pull
Ghitani N, Barik A, Szczot M, Thompson JH, Li C, Le Pichon CE, Krashes, MJ and Chesler, AT. Neuron, 2017. 95: p. 944-54.
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Sept. 5th 2017 - Jane Hartung (Gold lab)

Epiregulin and EGFR interactions are involved in pain processing
Martin, L. J., S. B. Smith, A. Khoutorsky, C. A. Magnussen, A. Samoshkin, R. E. Sorge, C. Cho, N. Yosefpour, S. Sivaselvachandran, S. Tohyama, T. Cole, T. M. Khuong, E. Mir, D. G. Gibson, J. S. Wieskopf, S. G. Sotocinal, J. S. Austin, C. B. Meloto, J. H. Gitt, C. Gkogkas, N. Sonenberg, J. D. Greenspan, R. B. Fillingim, R. Ohrbach, G. D. Slade, C. Knott, R. Dubner, A. G. Nackley, A. Ribeiro-da-Silva, G. G. Neely, W. Maixner, D. V. Zaykin, J. S. Mogil and L. Diatchenko. Journal of Clinical Investigation, 2017. in press.
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Sept. 12th 2017 - Colleen Cassidy (Koerber lab)

Distinct behavioral responses evoked by selective optogenetic stimulation of major TRPV1+ and MrgD+ subsets of C-fibers
Beady H., Daou I., Ase A.R., Ribeiro-de-Silva A., Seguela P. Pain, 2017. in press.

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Sept. 19th 2017 - Cancelled

Sept. 26th 2017 - Jami Saloman (Davis lab)

Gut microbiota is critical for the induction of chemotherapy-induced pain
Shen S., Lim G., You Z., Ding W., Huang P., Ran C., Doheny J., Caravan P., Tate S., Hu K., Kim H., McCabe M., Huang B., Xie Z., Kwon D., Chen L.,Mao J. Nature Neurosci, 2017. 20 (9): 2013-18.

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Oct. 3rd 2017 - Sarah Najjar (Albers lab)

Enterochromaffin cells are gut chemosensory that couple to sensory neural pathways
Bellano N.W., Bayrer J.R., Leitch D.B., Castro J., Zhang C., O'Donnell T.A., Brierley S.M., Ingraham H.A, Julius D. Cell, 2017. 170: 185-198.

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Oct. 10th 2017 - Cynthia Arokiaraj (Seal lab)

A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity
Tan L.L., Pelter P., Heinl C., Tang W., Gangadharan V., Flor H., Sprengel R., Kuner T., Kuner R. Nature Neurosci., 2017. Advanced online publication.

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Oct. 17th 2017 - Jorge Pineda (Gold lab)

miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes
Peng C., Li L., Zhang M.D., Gonzales C.B., Parisien M., Belfer I., Usoskin D., Abdo H., Furlan A., Haring M., Lallemand F., Harkany T., Diatchenko L., Hokfelt T., Hjerling-Leffler J., Ernfors P. Science, 2017, 356: 1168-1171. 

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Oct. 24th 2017 - Stephanie Puig (Gutstein lab)

Site-specific regulation of P2X7 receptor function in microglia gates morphine analgesic tolerance
Leduc-Pessah H., Weilinger N.L., Fan C.Y., Burma N.E., Thompson R.J., Trang T. J Neurosci, 2017, Advanced online publication. 

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Oct. 31st 2017 - Joe Salsovic (Koerber lab)

Nov. 7th 2017 - Kristen Smith Edwards (Davis lab)

Nov. 14th 2017 - SFN week

Nov. 21st 2017 - Thanksgiving break

Nov. 28th 2017 - Emanuel Loeza (Gold lab)

Dec. 5th 2017 - Jillian Weeks (Sved lab)

Dec. 12th 2017 - Junichi Hachisuka (Ross lab)

Journal Club Schedule Spring 2017

Jan. 3rd 2017 - John Horn

The sacral autonomic outflow is sympathetic
Espinosa-Medina I, Saha O, Boismoreau F, Chettouh Z, Rossi F, Richardson WD and Brunet JF. Science, 2016. 354(6314): p. 893 - 7.
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consensus: developmental biologists and physiologists come head-to-head!
discussion from this journal club led to an eLetter response in Science.

Jan. 10th 2017 - Cedric Peirs (Seal lab)

Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination
Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA and Lechner SG. Neuron, 2016. in press
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consensus: very cool paper and outstanding presentation. double kudos!

Jan. 17th 2017 - Qing Liu

Spinal inhibitory interneuron diversity delineate variant motor microcircuits
Bikoff J, Gabito MI, Rivard AF, Drobac E, Machado TA, Miri A, Brenner-Morton S, Famojure E, Diaz C, Alvarez FJ, Mentis GZ, and Jessel TM. Cell, 2016. 165(1) 207-219
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consensus: so many subtypes!

Jan. 24th 2017 - Keith Vogt

Different brain circuitries mediating controllable and uncontrollable pain
Brasher AK, Becker S, Hoeppli ME, Schweinhardt P. J Neurosci, 2016. 38(18):5013-5020
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consensus: this is an important question

Jan. 31st 2017 - Stephanie Puig (Gutstein Lab)

Loss of mu opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia
Corder G, Tawfik VL, Sypek EI, Low SA, Dickinson JR,Sotoudeh C, Clark JD, Barres, BA, Bohlen CJ, and Scherrer G. Nat Medicine, 2017.published online Jan. 16.
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consensus: so interesting -- lots of discussion!

Feb. 7th 2017 - Emanuel Loeza (Gold lab)

Reversible induction of pain hypersensitivity following ontogenetic stimulation of spinal astrocytes
Nam Y, Kim J-H, Kim J-H, Jha MK, Jung JY, Lee M-G, Choi I-S, Jang I-S, Lim DG, Hwang S-H, Cho H-J, Suk K. Cell Reports, 2016. 17, 3049-3061
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consensus: nice job Emanuel!

Feb. 14th 2017 - Tara Deemyad (Urban lab)**

Shank3 deficiency impairs heat hyperalgesia and TRPV1 signaling in primary sensory neurons
Han Q, Kin YH, Wang X, Liu D, Zhang Z-J, Bey AL, Lay M, Chang W, Berta T, Zhang Y, Jiang Y-H, Ji RR. Neuron, 2016. 92, 1279-1293
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consensus: novel presynaptic function for Shank!

Feb. 21st 2017 - Lindsey Snyder (Ross lab)

A brainstem-spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins
Francois A, Low SA, Sypek EI, Christensen AJ, Sotoudeh C, Beier KT, Ramakrishnan C, Ritola KD, Shariff-Naeini R, Deiseroth K, Delp SL,Malenka RC, Juo,L, Hantman AW, and Scherrer G. Neuron, 2017. 93, 1-18
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consensus: Tour de force highlighting cool viral experiments

Feb. 28th 2017 - Jane Hartung (Gold lab)

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents
Burma NE, Bonin RP, Leduc-Pessah H, Baimel C, Cairncross ZF, Mousseau M, Shankar JV, Stemkowski PL, Baimoukhametova D, Bains JS, Antle MC, Zamponi GW, Cahill CM, Borgland SL, De Koninck Y, Trang T. Nat Medicine, 2017. Jan 30 [Epub ahead of print]
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consensus: Intriguing results sparked a heated debate over the presence of opioid receptors in glial cells.

March 7th 2017 - Spring Break

March 14th 2017 - Michael Chiang (Ross lab)**

Leaky gate model: Intensity-dependent coding of pain and itch in the spinal cord
Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Neuron, 2017. 93, 840-853.
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consensus: this was the most hilarious journal club ever.

March 21st 2017 - Sarah Najjar (Albers lab)

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats
Ibrahim MM, Patwardhan A, Galbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R. Pain, 2017. 158 (2), 347-360.
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consensus: wow! this is very intriguing, and a huge caution for all of us doing real time place aversion with light.

March 28th 2017 - Jami Soloman (Davis lab)

PanIN neuroendocrine cells promoter tumorigenesis via neuronal crosstalk
Sinha S, Fu Y, Grimont A, Ketcham, M, Lafaro K, Saglimbeni JA, Askan G, Bailey JM, Melchior JP, Zhong Y, Joo MG, Grbovic-Huezo O, Yang IH, Basturn O, Baker L, Park Y, Kurtz RC, Tuveston D, Leach SD and Pasricha PJ. Cancer Research 2017. in press.
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consensus: cool insight into the mystery of neural-epithelial crosstalk in cancer — substance P!

April 4th 2017 - Colleen Cassidy (Koerber lab)

Small-molecule inhibition of STOML3 oligomerization reverses pathological hypersensitivity
Wetzel C, Pilfer S, Picci C, Gok C, Hoffman D,Bali KK, Lampe A,Lapatsina L, Fleischer R, St John Smith E, Begay V, Moroni M, Estebanez L, Kuhnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Tuner R, Poulet JFA, Schmoranger J, Poole K and Lewin G. Nature Neuroscience 2017. 20(2), 209-218.
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April 11th 2017 - Junichi Hachisuka (Ross lab)

Molecular and neural basis of contagious itch behavior in mice
Yu YQ, Barry DM, Hao Y, Liu XT, Chen ZF. Science 2017. 355, 1072-1076.
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consensus: the optogenetic data are pretty compelling -- who would of guessed that the SCN is involved in itch?

April 18th 2017 - Distinguished Speaker Lunch

April 25th 2017 - Cynthia Arokiaraj (Seal lab)

Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission
Du X,Hao H,Yang Y, Huang, S, Wang C, Gigot S, Ramli R, Li X, Jaworski E, Edwards I, Deuchars J, Yanagawa Y, QI J, Guan B, Jaffe DB, Zhang H, Gamper N. J Clin Invest 2017. April 4. [Epub ahead of print].
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Previous Journal Club Fall 2016

Aug. 30th 2017 - Maggie Wright (Koerber lab)

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
Osteen, J.D., V. Herzig, J. Gilchrist, J.J. Emrick, C. Zhang, X. Wang, J. Castro, S. Garcia-Caraballo, L. Grundy, G.Y. Rychkov, A.D. Weyer, Z. Dekan, E.A.B. Undheim, P. Alewood, C.L. Stucky, S.M. Brierley, A.I. Basbaum, F. Bosmans, G.F. King, and D. Julius. Nature, 2016. 534(7608): p. 494-499.
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  consensus: watch out for those spiders - fantastic presentation Maggie of a very interesting paper!

Sept. 6th 2016 - Jami Saloman (Davis lab)

Localized Sympathectomy Reduces Mechanical Hypersensitivity by Restoring Normal Immune Homeostasis in Rat Models of Inflammatory Pain
Xie, W., S. Chen, J. A. Strong, A. L. Li, I. P. Lewkowich and J. M. Zhang The Journal of neuroscience 2016.36(33): 8712-8725.
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  consensus: microsympa-wow! tricky surgery. very impressive!

Sept. 13th 2016 - Michael Chiang (Ross lab)

The coding of cutaneous temperature in the spinal cord
Ran C, Hoon MA, Chen X Nat Neurosci.  2016 Sep; 19(9):1201-9.
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  consensus: such an exciting proof of concept -- this is the future of understanding spinal microcircuits

Sept. 20th 2016 - Matt Rannals (Urban lab)**

GABA-b receptors tune cortical feedback to the olfactory bulb
Maza C, Lepousez, G, Nissant A, Valley MT and Lledo PM,  Nat Neurosci.  2016 Aug; 36(32):8289-8304.
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  consensus: nice job Matt, teasing apart the function of a particular synapse in top-down control!

Sept. 27th 2016 - Sarah Najjar (Albers lab)

Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain
Kim YS, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, Saijilafu, Young L, He S, LaVinka PC, Zhou F, Bergles D, Hanani M, Guan Y, Spray DC, Dong X. Neuron, 2016. 91(5): p. 1085-96.
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  consensus: excitatory communication between neurons generated excited communication among scientists.
Sarah, your journal club generated an outstanding discussion!

Oct. 4th 2016 - Cedric Peirs (Seal lab)

Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain
Cui L, Miao X, Liang L, Abdus-Saboor I, Olson W, Flemming MS, Ma M, Tao Y, Luo W. Neuron, 2016. 91(5): p. 1137-53.
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  consensus: these are some really powerful inhibitory interneurons!

Oct. 11th 2016 - Jorge Pineda (Gold lab)

The TRPM2 ion channel is required for sensitivity to warmth
Tan CH and Mcnaughton PA. Nature, 2016. 460(536).
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  consensus: we are feeling warm all over -- cool new heat transducer

Oct. 18th 2016 - Stephanie Puig (Gutstein lab)

GRK2 constitutively governs peripheral delta opioid receptor activity
Brackley, AD, Gomez, R, Akopian AN, Henry MA and Jeske NA. Cell Report, 2016. 16(2686).
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  consensus: location, location, location!

Oct. 25th 2016 - Colleen Cassidy (Koerber lab)

Merkel disc is a serotonergic synapse in the epidermis for transmitting tactile signals in mammals
Chang W, Kanda H, Ikeda, R, Ling J, De Berry, JJ, Gu JG PNAS, 2016. 113(37) E5491.
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  consensus: I like the feel of this!

Nov. 1st 2016 - Lindsey Snyder (Ross lab) **

Mapping sub-second structure in mouse behavior
Wiltschko AB, Johnson MG, Iurilli G, Peterson ER, Katon JS, Pashkovski SL, Abraira VE, Adams RP and Datta SR Neuron, 2015. 88(1121).
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  consensus: Great Journal Club! Can't wait to see improvements enabling the
  behaviors 

Nov. 8th 2016 - Melissa Giraldo Duque (Gold lab)

Social transfer of pain in mice
Smith ML, Hostetler CM, Heinricher MM, Ryabinin AE Science Advances, 2016. 2(10):e1600855.
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  consensus: sensitive creatures!

Nov. 15th 2016 - SfN week

Nov. 22nd 2016 - Thanksgiving week

Nov. 29th 2016 - Marissa Kuzirian (Ross lab)

Capturing and manipulating activated neuronal ensembles with CANE delineates a hypothalamic social-fear circuit
Sakurai K, Zhao S, Takatoh J, Rodriguez E, Lu J, Leavitt AD, Fu M, Han BX and Wang F Neuron, 2016. 92(1).
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  consensus: this paper was outstanding! What an awesome new tool!

Dec. 6th 2016 - Junichi Hachisuka (Ross lab)

In vivo interrogation of spinal mechanosensory circuits
Christensen AJ, Iyer SM, Francois A, Vyas S, Ramakrishnan C, Vesuna S, Deisseroth K, Scherrer G and Delp SL Cell Reports, 2016. 17(6)1699.
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  consensus: we're lighting up with excitement over this one!

Dec. 13th 2016 - Jane Hartung (Gold lab)

In vivo characterization of distinct modality-specific subsets of somatosensory neurons using GCaMP
Emery EC, Liuz, AP, Sikander S, Magnusdottir R, Dong X, Wood JN Science Advances, 2016. 2:e1600990.
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  consensus: surprisingly controversial. Wow!
  discussion from this journal club led to a heated debate 

Pain Research Forum